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January 14, 2015

Increased CoQ10 levels linked with reduced dementia risk


A recent study indicates that higher levels of the lipid-soluble antioxidant coenzyme Q10 (CoQ10) in older men and women is associated with a lower risk of developing dementia.

Read more about this research below.

In the United States, Alzheimer’s is the sixth leading cause of death annually and accounts for 50 to 80 percent of all dementias according to the Alzheimer’s Association.In a recent study published in the journal Atherosclerosis, researchers analyzed the association between CoQ10 and incidences of dementia.The researchers conducted population-based prospective cohort study of approximately 6000 Japanese subjects aged 45–70 years at baseline (1984–1994) who were followed for at least 5 years. Serum CoQ10 levels were measured in 65 men and women who developed disabling dementia with dementia-related behavioral disturbance or cognitive impairment during the follow-up period. CoQ10 levels were also measured in 130 age- and gender- matched control subjects.
Results showed that overall, subjects with higher CoQ10 levels had a decline in the risk of developing dementia. Subjects whose CoQ10 levels were among the highest 25% of participants had a risk of dementia that was 77% less than those whose levels were among the lowest 25%. A similar relationship was observed when the ratio of CoQ10 to total cholesterol was examined.Although more research is needed, this study shows that higher serum CoQ10 levels may have a beneficial effect on the prevention of dementia.

Momiyama, Yukihiko. Serum coenzyme Q10 levels as a predictor of dementia in a Japanese general population. Atherosclerosis,Volume 237,Issue 2,433 – 434. Dec. 2014.

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